A Lord of Calamity acquires their power due to a curse of immortality, which causes them to accumulate far more grief, despair, and negative emotions than most humans are capable of in their lifetimes; however, it is known that there were other Lords of Calamity in the distant past, and so other means to achieve the power may exist. It is implied that a powerful enough Shepherd can take the Lord of Calamity's place, and being able to form a contract with a dragon, in the same way the Shepherd forms contract with his seraph Prime Lords and Sub Lords, may be a requirement.
There are two known Lords of Calamity. The first Lord of Calamity to exist is Velvet Crowe, protagonist of the distant prequel Tales of Berseria, and the other is Heldalf, who was cursed with immortality and misfortune by the previous Shepherd, Michael, who sacrificed a baby, Mikleo, on an altar to the seraph Maotelus. The curse also brought death to all those close to Heldalf, including his newborn son, who was seemingly transforming into a hellion before being put down by Heldalf. Heldalf only realized his true form as the Lord of Calamity when he attempted to commit suicide by throwing himself onto an active battlefield. Unable to be struck down, the surplus of negativity on the battlefield empowered him into his current, lion-like form.
- During the early stages of Velvet's rampage, she was simply called the "Calamity" (災禍 Saika?).
- Velvet took the original title "Lord of Calamity," from a tale of the embodiment of sin told by Medissa. However, unlike Heldalf, who wanted to change the world into a world without pain by destroying it, Velvet actually helped save the world by killing Artorius Collbrande and sealing away Innominat who were planning to rob people of their emotions as well as individuality, and remove the people who would not accept this.