The village is located near the Tower of Salvation and surrounded by mountains, the Gaoracchia Forest, and a lake. The village chief is Igaguri, who has been in a coma for several years, leading the vice-chief Tiga to perform his duties in the meantime. The villagers' names are not their true names since only respected families of a person are granted this knowledge. The names of Sheena, Kuchinawa, and Orochi are aliases used as public identities. The village has a small islet, known as the Isle of Decision, where duels take place.
Tales of Symphonia
Sheena was forced to take Lloyd Irving and the others to Mizuho on their way to Ozette in an attempt to escape the Papal Knights pursuing them. Although the residents of the village are shocked at Sheena's actions, Tiga agrees to help the group, but only in exchange for allowing the people of Mizuho to move to Sylvarant, as they are considered traitors in Tethe'alla. Tiga instructs Sheena to accompany the group, now as a representative of Mizuho. After obtaining the "Zircon" from Altamira, it is possible to return to Mizuho in order to fight Kuchinawa in a one-on-one duel with Sheena.
Afterward, the group hears news that Igaguri is emerging from his coma, and Sheena reveals that Igaguri is her foster-grandfather, as he found her in the Gaoracchia Forest when she was young and cared for her. The group then wonders if it is possible that Igaguri's spirit is still in the Temple of Lightning after his battle against Volt many years prior, so they make their way to the temple. After the group manages to return Igaguri's spirit to his body, he declares to the people of Mizuho that Sheena will become his successor, and Sheena will obtain the title "Successor", which provides her with a new set of formal ninja wear in honor of her position.
- The name Mizuho is based on one of Japan's more ancient and poetic names. Likewise, the culture of the village, architecture of its buildings, and clothes and names of the villagers draw influence from the Sengoku period.